Global demand for exosome research products market was valued at approximately USD 82.36 million in 2018 and is expected to generate revenue of around USD 323.09 billion by end of 2025, growing at a CAGR of around 21.6% between 2019 and 2025
Exosome Research Products Market: Introduction
In Exosome Research Products Market Report, Introduction as Exosomes is extracellular lipid nanovesicles with a diameter of 30 to 120 nm. Different cells secrete these substances, which are present in all bodily fluids including urine, plasma, saliva, serum, and cerebrospinal fluid (CSF). The release of exosomes occurs either upon induction or constitutively, in a regulated, dynamic, and functionally relevant manner, under both pathological and normal conditions.
Exosomes are isolated from various cell lines, including tumor lines, primary cultures, hematopoietic cells, and virus-infected cells, as well as biological fluids in the blood, including plasma and serum from cancer patients and other body fluids, including pleural effusions, bronchoalveolar lavage fluid, amniotic fluid, synovial fluid, semen, saliva, and urine.
Exosomes have multiple functions, both physiological and pathological. These play an important role in a variety of pathological conditions, including infectious, cancerous, and neurodegenerative disorders.
Challenges: Lack of gold standard protocols for exosome development and production
The field of exosomes is still in its infancy, and no gold standards have yet been established. Therefore, professionals employ newly introduced procedures and methodologies without hesitation. In addition to making mistakes during exosome production, scientists face numerous obstacles during exosome research, development, and production. Recent interest has increased in exosomes derived from MSCs due to their ability to act as intercellular messengers.
Their unique property makes them desirable for biomedical applications including vaccine development, cancer diagnosis, cell therapy, gene therapy, and drug delivery.
Therefore, MSC-exosome therapy developers must modify their stem cell-free therapy workflow in light of new exosome production requirements in order to develop efficient exosome harvesting methods and establish gold standards for exosome characterization and purification.
Impact of COVID-19 on the Global Exosome Research Market
Presently, the FDA has not approved a single antiviral drug for COVID-19, and there is an urgent need to develop therapeutic strategies that can effectively suppress SARS-CoV-2 infections. Numerous approaches, including emerging exosome-based therapies, have been investigated.
The interaction between exosomes and viruses could be utilised to develop antiviral drugs and vaccines. Exosomes are produced by infected cells and play crucial roles in facilitating communication between uninfected and infected cells. Coronavirus modulates exosome production and composition and can exploit exosome secretion, formation, and release pathways to promote infection, transmission, and intercellular spread.
Thus, the possibility of using exosomes for therapeutic purposes creates lucrative opportunities for entities operating in this industry; numerous companies are participating in clinical trials and driving the market for research products and services.
Experimental and clinical studies are examining the therapeutic potential of MSCs and exosomes in reducing COVID-19 mortality and morbidity. However, additional preclinical and clinical research is required to develop an effective exosome-based treatment for COVID-19 patients.
In the midst of the pandemic, there has been a resurgence of interest among research professionals in the applicability of exosomes, and efforts are being made to develop effective and safe therapeutics for combating COVID-19-associated diseases.
As of November 2020, seven clinical trials to assess the safety of exosome-based therapeutic strategies for COVID-19-positive patients have been submitted.
In terms of product and service, the kits & reagents segment dominated the exosome research market in 2020.
The exosome research market is segmented by product and service into kits & reagents, instruments, and services. The kits & reagents segment is subdivided further into antibodies, isolation, purification, quantitation, and additional kits & reagents. Circulating exosomal microRNAs (miRNAs) have emerged as promising biomarker candidates, necessitating careful characterization of these exosomes.
This has propelled the use of these entities in exosome research to create kits and reagents that are simple to use. In addition, isolation and purification are essential steps in exosome research protocols, which contributes to their widespread market adoption.
In 2020, cancer represented the largest indication segment of the exosome research market.
On the basis of indication, the market for exosome research is segmented into cancer, neurodegenerative diseases, cardiovascular diseases, infectious diseases, and others.
The lung cancer, prostate cancer, breast cancer, colorectal cancer, and other cancers segments the market for exosome research in cancer. The high demand for exosome research products and services in lung cancer management is responsible for the cancer segment’s large market share.
In terms of application, biomarkers held the largest share of the exosome research market in 2020.
The exosome research products market is segmented on the basis of application into biomarkers, vaccine development, tissue regeneration, and other applications. In terms of revenue, the biomarkers segment dominated the exosome research market in 2020.
Exosomes can be isolated from readily accessible biofluids, such as blood, urine, and saliva; this facilitates their use as disease management biomarkers. Exosomes are also being utilized in the development of vaccines against the COVID-19 virus, which accounts for the segment’s rapid growth rate.
In terms of end users, the academic & research institutes segment dominated the exosome research market in 2020.
The exosome research market is segmented by end-user into academic & research institutes, hospital & clinical testing laboratories, and pharmaceutical & biotech companies.
In recent years, there has been an increase in demand for exosome research due to their potential in disease diagnosis and their emerging role as intercellular messengers. This has piqued the interest of academic research professionals, which has contributed to the market dominance of academic & research institutes.
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